Allele-Sharing Models: LOD Scores and Accurate Linkage Tests
نویسندگان
چکیده
منابع مشابه
Allele-sharing models: LOD scores and accurate linkage tests.
Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software. Most important, accurate linkage tests can be performed. Using an example, we show that some ...
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Several methods have been proposed for linkage analysis of complex traits with unknown mode of inheritance. These methods include the LOD score maximized over disease models (MMLS) and the "nonparametric" linkage (NPL) statistic. In previous work, we evaluated the increase of type I error when maximizing over two or more genetic models, and we compared the power of MMLS to detect linkage, in a ...
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We performed multipoint linkage analyses with multiple programs and models for several gene expression traits in the Centre d'Etude du Polymorphisme Humain families. All analyses provided consistent results for both peak location and shape. Variance-components (VC) analysis gave wider peaks and Bayes factors gave fewer peaks. Among programs from the MORGAN package, lm_multiple performed better ...
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The calculation of exact likelihoods from pedigree data is limited to datasets containing either a small number of meioses, or a small number of linked genetic loci. In particular, the computation of likelihoods from data collected at multiple loci on large, extended pedigrees is infeasable. We perform multipoint linkage analysis on such datasets by estimating ratios of these otherwise intracta...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 1997
ISSN: 0002-9297
DOI: 10.1086/301592